小檔案

學 歷

美國南阿拉巴馬州立大學博士 (1989-1994)

國立師範大學生物系學士 (1982-1986)

經 歷

成功大學醫學院微免所教授 (2009-present)

成功大學醫學院微免所副教授 (2003-2009)

美國哈佛大學醫學院生化及分子藥理系博士後研究 (1994-1998)

國立師範大學生物系助教 (1987-1989)

臺中縣立中平國中生物科教師 (1986-1987)

專長學門

分子病毒學

免疫學

分子生物學

研究興趣

探討神經性病毒引起腦炎的治病機制及其免疫調控。

研究疱疹病毒如何與宿主之基因作用，進而引起致命性腦炎，並探討感染後病毒在腦部的潛伏復發及免疫調控。

研究腸病毒七十一型引起致命性腦炎的機制，免疫調控及治療方法。

PUBLICATIONS

1.         Chen SH, Oakes JE, and Lausch RN (1993) Synergistic anti-HSV effect of tumor necrosis factor and interferon gamma in human corneal fibroblasts is associated with interferon beta induction. Antiviral Res. 22: 15-29 (SCI).

2.         Chen SH, Oakes JE, and Lausch RN (1994) Synergistic anti-herpes effect of TNF-alpha and IFN-gamma in human corneal epithelial cells compared with that in corneal fibroblasts. Antiviral Res. 25: 201-213 (SCI).

3.         Tumpey T M, Elner VM, Chen SH, Oakes JE, and Lausch RN (1994) Interleukin 10 treatment can suppress stromal keratitis induced by herpes simplex virus type 1. J. Immunol. 153: 2258-2265 (SCI).

4.         Tumpey TM, Chen SH, Oakes JE, and Lausch RN (1996) Neutrophil-mediated suppression of virus replication following HSV-1 infection of the murine cornea. J. Virol. 70: 898-904 (SCI).

5.         Lausch RN, Chen SH, Tumpey T M, Su YH, and Oakes JE. (1996) Early cytokine synthesis and interaction in the traumatized mouse cornea. J. Interferon and Cytokine Res. 16: 35-40 (SCI)

6.         Chen SH, Kramer MF, Schaffer PA, and Coen DM (1997) A viral function repress accumulation of transcripts from productive cycle genes in mouse ganglia latently infected with herpes simplex virus. J. Virol. 71: 5878-5884 (SCI)

7.         Kramer MF, Chen SH, Knipe DM, and Coen DM (1998) Accumulation of viral transcripts and DNA during establishment of latency by herpes simplex virus. J. Virol. 72: 1177-1185 (SCI).

8.         Jacobson JG, Chen SH, Cook WJ, Kramer MF, and Coen DM (1998) Importance of the herpes simplex virus UL24 gene for productive infection in mice. Virology. 242: 161-169 (SCI).

9.         Chen SH, Cook WJ, Grove KL, and Coen DM (1998) Human thymidine kinase can functionally replace herpes simplex virus type 1 thymidine kinase for viral replication in mouse sensory ganglia and reactivation from latency upon explant. J. Virol. 72: 6710-6715 (SCI).

10.    Horshurgh BC, Chen SH (Co-first author), Hu A, Mulamba GB, Burn WH, and Coen DM (1998) Recurrent acyclovir-resistant HSV infection in an immunocompromised patients: Can strain differences compensate for loss of thymidine kinase in pathogenesis. J. Infect. Dis. 178: 618-625 (SCI).

11.    Chen SH, Garber DA, Schaffer PA, Knipe DM, and Coen DM (2000) Persistent elevated expression of cytokine transcripts in ganglia latently infected with herpes simplex virus in the absence of ganglionic replication or reactivation. Virology 278: 207-216 (SCI).

12.    Lei HY, Yeh TM, Liu HS, Lin YS, Chen SH, and Liu CC. (2001) Immuno-pathogenesis of dengue virus infection. J. Biomed. Sci. 8: 377-388 (SCI)

13.    Chen YL, Wang JY, Chen SH, and Yang BC. (2002) Granulocytes mediates the Fas-L associated apoptosis during lung metastasis of melanoma that determines the metastatic behavior. Br. J. Cancer. 87: 359-365 (SCI).

14.    Chen SH (correspondence), Lee LY, Garber DA, Schaffer PA, Knipe DM, and Coen DM (2002) Neither LAT nor ORP-P mutations increase expression of spliced or intron-containing ICP0 transcripts in mouse ganglia latently infected with herpes simplex virus. J. Virol. 76: 4764-4772 (SCI).

15.    Lin CF, Lei HY, Shiau AL, Liu HS, Yeh TM, Chen SH, Liu CC, Chiu SC, and Lin YS (2002) Endothelial cell apoptosis induced by antibodies against dengue virus nonstructural protein 1 via production of nitric oxide. J. Immunol. 169: 657-664 (SCI).

16.    Lin YL, Lei HY, Lin YS, Yeh TM, Chen SH, Liu HS. (2002) Heparin inhibits dengue-2 virus infection of five human liver cell lines. Antiviral Res. 56: 93-96 (SCI).

17.    Lin YW, Wang KJ, Lei HY, Lin YS, Yeh TM, Liu HS, Liu CC, and Chen SH (correspondence) (2002) Virus replication and cytokine production in dengue virus-infected human B lymphocytes. J. Virol. 76: 12242-12249 (SCI).

18.    Lin CF, Lei HY, Shiau AL, Liu CC, Liu HS, Yeh TM, Chen SH, and Lin YS. (2003) Antibodies from dengue patient sera cross-react with endothelial cells and induce damage. J. Med. Virol. 69: 82-90 (SCI)

19.    Griffiths A, Chen SH, Horshurgh BC, and Coen DM (2003) Translation compensation of a frameshift mutation affecting herpes simplex virus thymidine kinase is sufficient to permit reactivation from latency. J. Virol. 77: 4703-4709 (SCI).

20.    Huang YH, Lei HY, Liu HS, Lin YS, Chen SH, Liu CC, and Yeh TM (2003) Tissue plasmingoen activator induced by dengue virus infection of human endothelial cells. J. Med. Virol. 70: 610-616 (SCI) 

21.    Chen YL, Chen SH, Wang JY, and Yang BC (2003) FasL on tumor cells mediates inactivation of neutrophils. J. Immunol. 171: 1183-1191 (SCI).

22.    Wu HM, Huang CC, Chen SH, Liang YC, Tsai JJ, Hsieh CL, and Hsu KS (2003) Herpes simplex virus type 1 inoculation enhances hippocampal excitability and seizure susceptibility in mice. Eur. J. Neurosci. 18: 3294-3304 (SCI).

23.    Lin YS, Lin CF, Lei HY, Liu HS, Yeh TM, Chen SH, and Liu CC (2004) Antibody-mediated endothelial cell damage via nitric oxide. Curr. Pharm. Des. 10: 213-221 (SCI)

24.    Chen SH, Pearson A, Coen DM, and Chen SH (correspondence) (2004) Failure of thymidine kinase-negative herpes simplex virus to reactivate from latency following efficient establishment. J. Virol. 78: 520-523 (SCI).

25.    Wang YF, Chou CT, Lei HY, Liu CC, Wang SM, Yan JJ, Su IJ, Wang JR, Yeh TM, Chen SH, and Yu CK (2004) A mouse-adapted enterovirus 71 strain causes neurological disease in mice after oral infection. J. Virol. 78: 7916-24 (SCI)

26.    Chen SF, Huang CC, Wu HM, Chen SH, Liang YC, and Hsu KS (2004) Seizure, neuron loss, and mossy fiber sprouting in herpes simplex virus type 1-infected organotypic hippocampal cultures. Epilepsia 45: 322-32 (SCI)

27.    Wu HM, Liang YC, Chen SH, Huang CC, Chen SH, Tsai JJ, Hsieh CL, and Hsu KS (2004) Valacyclovir treatment ameliorates the persistently increased pentylenetetrazol-induced seizure susceptibility in mice with herpes simplex virus type 1 infection. Exp. Neurol. 189: 66-77 (SCI).　

28.    Lin CF, Lei HY, Liu CC, Liu HS, Yeh TM, Chen SH, and Lin YS (2004) Autoimmunity in dengue virus infection. Dengue Bulletin 28: 51-57 (SCI).

29.    Liang CC, Sun MJ, Lei HY, Chen SH, Yu CK, Liu CC, Wang JR, Yeh TM (2004) Human endothelial cell activation and apoptosis induced by enterovirus 71 infection. J. Med. Virol. 74: 597-603 (SCI)

30.    Lin CF, Chiu SC, Hsiao YL, Wan SW, Lei HY, Shiau AL, Liu HS, Yeh TM, Chen SH, Liu CC, and Lin YS (2005) Expression of cytokine, chemokine, adhesion molecules during endothelial cell activation induced by antibodies against dengue virus nonstructural protein 1. J. Immunol. 174: 395-403 (SCI).

31.    Lee YR, Huang KJ, Lei HY, Chen SH, Lin YS, Yeh TM, and Liu HS (2005) Suckling mice were used to detect infectious dengue-2 viruses by intracerebral injection of the full-length RNA transcript. Intervirology 48: 161-166 (SCI).

32.    Weng TY, Chen LC, Shyu HW, Chen SH, Wang JR, Yu CK, Lei HY, and Yeh TM (2005) Lactoferrin inhibits enterovirus 71 infection by binding to VP1 protein and host cells. Antiviral Res. 67: 31-35 (SCI).

33.    Liu ML, Lee YP, Wang YF, Lei HY, Liu CC, Wang SM, Su IJ, Wang JR, Yeh TM, Chen SH, and Yu CK (2005) Type I interferons protect mice against enterovirus 71 infection. J. Gen. Virol. 86: 3263-9 (SCI).

34.    Chen LC, Lei HY, Liu CC, Shiesh SC, Chen SH, Liu HS, Lin YS, Wang ST, Shyu HW, and Yeh TM (2006) Correlation of serum levels of macrophage migration inhibitory factor with disease severity and clinical outcome in dengue patients. Am. J. Trop. Med. Hyg. 74: 142-147 (SCI).　

35.    Chen LC, Shyu HW, Chen SH, Lei HY, Yu CK, and Yeh TM (2006) Enterovirus 71 infection induces Fas ligand expression and apoptosis of Jurkat cells. J. Med. Virol. 78: 780-786 (SCI).

36.    Huang KJ, Yang YC, Lin YS, Huang JH, Liu HS, Yeh TM, Chen SH, Liu CC, and Lei HY (2006) The dual-specific binding of dengue virus and target cells for the antibody-dependent enhancement of dengue virus infection. J. Immunol. 176: 2825-2832 (SCI).

37.    Jean JS, Guo HR, Chen SH, Liu CC, Chang WT, Yang YJ, and Huang MC (2006) The association between rainfall rate and occurrence of an enterovirus epidemic due to a contaminated well. J. Appl. Microbiol. 101:1224-1231 (SCI).

38.    Chen SH, Lin YW, Griffiths A, Huang WY, and Chen SH (correspondence) (2006) Competition and complementation between thymidine kinase-negative and wild-type herpes simplex virus during co-infection of mouse trigeminal ganglia. J. Gen. Virol. 87: 3495-3502 (SCI).

39.    Lee YR, Liu MT, Lei HY, Liu CC, Wu JM, Tung Yc, Lin YS, Yeh TM, Chen SH, and Liu HS (2006) MCP-1, a highly expressed chemokine in dengue haemorrhagic fever/dengue shock syndrome patients, may cause permeability change, possibly through reduced tight junctions of vascular endothelium cells. J. Gen. Virol. 87: 3623-3630 (SCI).

40.    Chen SH, Yao HW, Huang WY, Hsu KS, Lei HY, Shiau AL, and Chen SH (correspondence) (2006) Efficient reactivation of latent herpes simplex virus from mouse central nervous system tissues. J. Virol. 80: 12387-12392 (SCI).

41.    Lee YR, Su CY, Chow NH, Lai WW, Lei HY, Chang CL, Chang TY, Chen SH, Lin YS, Yeh TM, and Liu HS (2007) Dengue viruses can infect human primary lung epithelia as well as lung carcinoma cells, and can also induce the secretion of IL-6 and RANTES. Virus Res. 126: 216-225. (SCI).

42.    Lee YR, Hung NT, Liu CC, Huang KJ, Lei HY, Lin YS, Wang JR, Yeh TM, Chen SH, and Liu HS (2008) Correlation of IFN-inducible protein 10 levels in sera with disease severity and clinical outcome of the dengue patients. American J. Infect. Dis. 4: 18-21.

43.    Chen LC, Shyu HW, Lei HY, Chen SH, Liu HS, Lin YS, and Yeh TM (2008) Dengue virus infection induced NF-kB-dependent macrophage migration inhibitory factor production. American J. Infect. Dis. 4: 22-31.

44.    Lee YR, Lei HY, Chen SH, Wang JR, Lin YS, Yeh TM, Liu CC, and Liu HS (2008) Signal pathways involved in dengue-2 virus infection induced by RANTES overexpression. American J. Infect. Dis. 4: 32-40.

45.    Li ZH, Li CM, Ling P, Shen FH, Chen SH, Yu CK, and Chen SH (correspondence) (2008) Ribavirin reduces the mortality of enterovirus 71-infected mice by decreasing viral replication. J. Infect. Dis. 197: 854-857 (SCI).

46.    Lee YR, Lei HY, Liu MT, Wang JR, Chen SH, Lin YS, Yeh TM, Liu CC, and Liu HS (2008) Autophagic machinery activated by dengue virus enhances viral replication. Virology 374: 240-248 (SCI).

47.  Chen SH, Yao HW, Chen IT, Shieh B, Li C, and Chen SH (correspondence) (2008) Suppression of transcription factor early growth response 1 reduces herpes simplex virus lethality in mice. J. Clin. Invest. 118: 3470-3477 (SCI).

48.  Lee CH, Wu CL, Chen SH, and Shiau AL (2009) Humoral immune responses inhibit the antitumor activities mediated by Salmonella enterica Serovar choleraesuis. J. Immunotherapy 32: 376-388. (SCI)

49.  Lin YW, Chang KC, Kao CM, Chang SP, Tung YY, and Chen SH (correspondence) (2009) Lymphocyte and antibody responses reduce enterovirus 71 lethality in mice by decreasing tissue viral loads. J. Virol. 83: 6477-6483 (SCI).

50.  Tsai CC, Kai JI, Huang WC, Wang CY, Wang Y, Chen CL, Fang YT, Lin YS, Anderson R, Chen SH, Tsao CW, and Lin CF (2009) Glycogen synthase kinase-3 facilitates IFN-γ-Induced STAT1 activation by regulating Src homology-2 domain-containing pohosphatase 2. J. Immunol. 183: 856-864 (SCI). 

51.  Lin YW, Wang SW, Tung YY, and Chen SH (correspondence) (2009) Enterovirus 71 infection of human dendritic cells. Exp. Bio. Med. 234: 1166-1173 (SCI).

52.  Huang WY, Su YH, Yao HW, Ling P, Tung YY, Chen SH, Wang X, and Chen SH (correspondence) (2010) Interferon beta plus gamma efficiently reduces acyclovir-resistant herpes simplex virus infection in mice in a T-cell-independent manner. J. Gen. Virol. 91: 591-598 (SCI).　

53.  Chang YP, Tsai CC, Huang WC, Wang CY, Chen CL, Lin YS, Kai JI, Hsieh CY, Cheng YL, Choi PC, Chen SH, Chang SP, Liu HS, and Lin CF (2010) Autophagy facilitates IFN-gamma-induced Jak2-STAT1 activation and cellular inflammation. J. Biol. Chem. 285: 28715-28722 (SCI).　

54.  Chang CH, Lai LC, Cheng HC, Chen KR, Syue YZ, Lu HC, Lin WY, Chen SH, Huang HS, Shiau AL, Lei HY, Qin J, and Ling P (2011) TBK1-associated protein in endolysosomes (TAPE) is an innate immune regulator modulating the TLR3 and TLR4 signaling pathways. J. Biol. Chem. 286: 7043-7051 (SCI).

55.  Hsiao YH, Chen PS, Chen SH, and Gean PW (2011) The involvement of Cdk5 activator in social isolation-triggered onset of early Alzheimer’s-related cognitive deficit in the transgenic mice. Neuropsychopharmacology 36: 1848-1858 (SCI).

56.  Lin SY, Dhillon V, Jain S, Chang TT, Hu CT, Lin YJ, Chen SH, Chang KC, Song W, Yu L, Block TM, and Su YH (2011) A locked nucleic acid clamp-mediated polymerase chain reaction assay for detection of a P53 codon 249 hotspot mutation in urine. J. Mol. Diagn. 13: 474-484 (SCI).

57.  Tsai CC, Huang WC, Chen CL, Hsieh CY, Lin YS, Chen SH, Yang KC, and Lin CF (2011) Glycogen synthase kinase-3 facilitates Con A-induced IFN-gamma-mediated immune hepatic injury. J. Immunol. 187:3867-3877 (SCI).

58.  Jain S, Chang TT, Hamilton JP, Lin SY, Lin YJ, Evans AA, Selaru FM, Lin PW, Chen SH, Block TM, Hu CT, Song W, Meltzer SJ, and Su YH (2011) Methylation of the CpG sites only on the sense strand of the APC gene is specific for hepatocellular carcinoma. PLoS ONE 6:e26799 (SCI).

59.    Ko CY, Chang LH, Lee YC, Sterneckd E, Cheng CP, Chen SH (3^rd author), Huang AM, Tseng JT, and Wang JM (2012) CCAAT/enhancer binding protein delta (CEBPD) elevating PTX3 expression inhibits macrophage-mediated phagocytosis of dying neuron cells. Neurobiol. Aging 33:422.e11-422.e25 (SCI).

60.  Hsiao YH, Kuo JR, Chen SH, and Gean PW (2012) Amelioration of social isolation-triggered onset of early Alzheimer’s disease-related cognitive deficit by N-acetylcysteine in a transgenic mouse model. Neurobiol. Dis. 45: 1111-1120 (SCI).

61.  Jain S, Chen S, Chang KC, Lin YJ, Hu CT, Boldbaatar1 B, Hamilton JP, Lin SY, Chang TT, Chen SH, Song W, Meltzer SJ, Block TM, and Su YH (2012) Impact of the location of CpG methylation within the GSTP1 gene on its specificity as a DNA marker for hepatocellular carcinoma. PLoS ONE 7: e35789 (SCI).

62.  Yao HW, Chen SH, Li C, Tung YY, and Chen SH (correspondence) (2012) Suppression of transcription factor early growth response 1 reduces herpes simplex virus 1-induced corneal disease in mice. J. Virol. 86: 8559-8567 (SCI).

63.  Hsieh CY, Chen CL, Tsai CC, Huang WC, Tseng PC, Lin YS, Chen SH, Wong TW, Choi PC, and Lin CF (2012) Inhibiting glycogen synthase kinase-3 decreases 12-O-tetradecanoylphorbol-13-acetate-induced interferon-gamma-mediated skin inflammation. J. Pharmacol. Exp. Ther. 343: 125-133 (SCI).

64.  Yao HW, Ling P, Chen SH, Tung YY, and Chen SH (correspondence) (2012) Factors affecting herpes simplex virus reactivation from the explanted mouse brain. Virology 433: 116-123 (SCI).

65.  Wang LC, Kao CM, Ling P, Chang TM, Su IJ, and Chen SH  (correspondence) (2012) CD4 T-cell-independent antibody response reduces EV 71 lethality in mice by decreasing tissue viral loads. Clin. Dev. Immunol. vol. 2012, Article ID 580696, 9 pages, 2012. doi:10.1155/2012/580696 (SCI).

66.  Shen FH, Tsai CC, Wang LC, Chang KC, Tung YY, Su IJ and Chen SH (correspondence) (2013) Enterovirus 71 infection increases expression of interferon-gamma-inducible protein 10 which protects mice by recruiting lymphocytes to reduce viral burden in multiple organs. J. Gen. Virol. 94: 1019-1027 (SCI).

67.  Shen FH, Wang SW, Yeh TM, Tung YY, Hsu SM, and Chen SH (correspondence) (2013) Absence of CXCL10 aggravates herpes stromal keratitis with reduced primary neutrophil influx in mice. J. Virol. 87: 8502-8510 (SCI).

68.  Shen PC, Shiau AL, Lee CH, Yang SJ, Lee BO, Jou IM, Wu CL, Chen SH, Hsieh JL (2013) CD8⁺ T cell-induced expression of tissue inhibitor of metalloproteinses-1 exacerbated osteoarthritis. Int. J. Mol. Sci. 14: 19951-19970 (SCI).

69.  Yao HW, Lin PH, Shen FH, Perng GC, Tung YY, Hsu SM, and Chen SH (correspondence) (2014) Tranylcypromine reduces herpes simplex virus 1 infection in mice. Antimicrob. Agents Chemother. 58: 2807-2815 (SCI).

70.    Shen FH, Shen TJ, Chang TM, Su IJ, and Chen SH (correspondence) (2014) Early dexamethasone treatment exacerbates enterovirus 71 infection in mice. Virology 464-465: 218–227 (SCI).

71.    Yao HW, Ling P, Tung YY, Hsu SM, and Chen SH (correspondence) (2014) In vivo reactivation of latent herpes simplex virus 1 in mice can occur in the brain before in the trigeminal ganglion. J. Virol. 88: 11264-11270 (SCI).

72.    Hsiao YH, Hung HC, Chen SH, and Gean PW (2014) Social interaction rescues memory deficit in an animal model of Alzheimer's disease by increasing BDNF-dependent hippocampal neurogenesis. J. Neurosci. 34(49):16207-16219 (SCI).

73.    Hsu SM, Yang CH, Shen FH, Chen SH, Lin CJ, and Shieh CC (2014) Proteasome inhibitor bortezomib suppresses nuclear factor-kappa B activation and ameliorates eye inflammation in experimental autoimmune uveitis. Mediat. Inflamm. Vol. 2014, Article ID 847373, 11 pages (SCI).

74.     Jain S, Xie L, Boldbaatar B, Lin S, Hamilton J, Meltzer S, Chen SH, Hu CT, Block T, Song W, Su YH. (2014) Differential methylation of the promoter and first exon of the RASSF1A gene in hepatocarcinogenesis. Hepatol. Res. doi: 10.1111/hepr.12449 (SCI).

75.    Lin TW, Shih YH, Chen SJ, Lien, CH, Chang CY, Huang TY, Chen SH, Jen CY, Kuo YM (2015) Running exercise delays neurodegeneration in amygdala and hippocampus of Alzheimer's disease (APP/PS1) transgenic mice. Neurobiol Learn Mem. 118:189-197 (SCI).

76.    Su PY, Wang YF, Huang SW, Lo YC, Wang AH, Wu SR, Shieh DB, Chen SH, Wang JR, Lai MD, and Chang CF (2015) Cell surface nucleolin facilitates enterovirus 71 binding and infection. J. Virol. 89 (8) 4527-4538 (SCI).  

77.    Cheong MW, Kuo LH, Cheng YN, Tsai PJ, Ho LC, Tai HC, Chiu WT, Chen SH, Lu PJ, Shan YS, Chuang LM, and Tsai YS (2015) Loss of Egr-1 sensitizes pancreatic β-cells to palmitate-induced ER stress and apoptosis. J. Mol. Med. 93:807-818 (SCI).

78.    Wang LC, Chen SO, Chang SP, Lee TP, Yu CK, Chen CL, Tseng PC, Hsieh CY, Chen SH (correspondence), and Lin CF. (2015) Enterovirus 71 proteins 2A and 3D antagonize the antiviral activity of IFN-γ via signaling attenuation J. Virol. 89 (14) 7028-7037 (SCI)

79.    Lin YL, Chen SH, Wang JY (2016) Critical role of IL-6 in the development of dendritic cell-induced allergic inflammation of asthma. J. Mol. Med. 94(1):51-9 (SCI)